Page 145 - Haematologica3

BCR internalization and signaling in CLL
9. Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signal- ing in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007;109(10):4424-4431.
10. Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118(16):4313-4320.
11. Jain P, Keating M, Wierda W, et al. Outcomes of patients with chronic lympho- cytic leukemia after discontinuing ibrutinib. Blood. 2015;125(13):2062-2067.
12. Guieze R, Robbe P, Clifford R, et al. Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL. Blood. 2015; 126(18):2110-2117.
13. Woyach JA, Smucker K, Smith LL, Lozanski A, Zhong Y, Ruppert AS, et al. Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular character- istics and does not indicate a suboptimal response to therapy. Blood. 2014 Mar 20;123(12):1810-1817.
14. Vuillier F, Dumas G, Magnac C, et al. Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associat- ed with glycosylation and folding defects of the mu and CD79a chains. Blood. 2005;105(7):2933-2940.
15. Williams GT, Venkitaraman AR, Gilmore DJ, Neuberger MS. The sequence of the mu transmembrane segment determines the tis- sue specificity of the transport of immunoglobulin M to the cell surface. J Exp Med. 1990;171(3):947-952.
16. Guo B, Zhang L, Chiorazzi N, Rothstein TL. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia. Blood. 2016;128(4):553-562.
17. Aguilar-Hernandez MM, Blunt MD, Dobson R, et al. IL-4 enhances expression and func- tion of surface IgM in CLL cells. Blood. 2016;127(24):3015-3025.
18. Krysov S, Potter KN, Mockridge CI, et al. Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo. Blood. 2010;115(21):4198-4205.
19. Coelho V, Krysov S, Steele A, et al. Identification in CLL of circulating intraclon- al subgroups with varying B-cell receptor expression and function. Blood. 2013;122(15):2664-2672.
20. Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B- cell receptor signaling, NF-kappaB activa-
tion, and tumor proliferation in chronic lym- phocytic leukemia. Blood. 2011;117(2):563- 574.
21. Ghia P, Strola G, Granziero L, et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur J Immunol. 2002;32(5):1403-1413.
22. Patten PE, Buggins AG, Richards J, et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microen- vironment. Blood. 2008;1 11(10):5173-5181.
23. Os A, Burgler S, Ribes AP, et al. Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells. Cell Rep. 2013;4(3):566-577.
24. Pascutti MF, Jak M, Tromp JM, et al. IL-21 and CD40L signals from autologous T cells can induce antigen-independent prolifera- tion of CLL cells. Blood. 2013; 122(17):3010- 3019.
25. Ghia P, Stamatopoulos K, Belessi C, et al. ERIC recommendations on IGHV gene mutational status analysis in chronic lym- phocytic leukemia. Leukemia. 2007;21(1):1- 3.
26. Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002; 100(4):1410-1416.
27. Cabezudo E, Carrara P, Morilla R, Matutes E. Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders. Haematologica. 1999; 84(5):413- 418.
28. Calissano C, Damle RN, Hayes G, et al. In vivo intraclonal and interclonal kinetic het- erogeneity in B-cell chronic lymphocytic leukemia. Blood. 2009;114(23):4832-4842.
29. Pasikowska M, Walsby E, Apollonio B, et al. Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration. Blood. 2016;128(4):563-573.
30. Blery M, Tze L, Miosge LA, Jun JE, Goodnow CC. Essential role of membrane cholesterol in accelerated BCR internaliza- tion and uncoupling from NF-kappa B in B cell clonal anergy. J Exp Med. 2006; 203(7):1773-1783.
31. Vilen BJ, Nakamura T, Cambier JC. Antigen- stimulated dissociation of BCR mIg from Ig- alpha/Ig-beta: implications for receptor desensitization. Immunity. 1999;10(2):239- 248.
32. Hou P, Araujo E, Zhao T, et al. B cell antigen
receptor signaling and internalization are mutually exclusive events. PLoS Biol. 2006;4(7):e200.
33. Lanemo Myhrinder A, Hellqvist E, Sidorova E, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacte- ria are targets for chronic lymphocytic leukemia antibodies. Blood. 2008;111(7): 3838-3848.
34. Goh LK, Sorkin A. Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 2013;5(5):a017459.
35. Herman SE, Niemann CU, Farooqui M, et al. Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: correla- tive analyses from a phase II study. Leukemia. 2014;28(11):2188-2196.
36. Herndon TM, Chen SS, Saba NS, et al. Direct in vivo evidence for increased prolif- eration of CLL cells in lymph nodes com- pared to bone marrow and peripheral blood. Leukemia. 2017;31(6):1340-1347.
37. Kowalewski DJ, Schuster H, Backert L, et al. HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci U S A. 2015;112(2):E166-175.
38. Hall AM, Vickers MA, McLeod E, Barker RN. Rh autoantigen presentation to helper T cells in chronic lymphocytic leukemia by malignant B cells. Blood. 2005;105(5):2007- 2015.
39. Trojan A, Schultze JL, Witzens M, et al. Immunoglobulin framework-derived pep- tides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies. Nat Med. 2000;6(6):667-672.
40. Rezvany MR, Jeddi-Tehrani M, Rabbani H, et al. Autologous T lymphocytes may specifically recognize leukaemic B cells in patients with chronic lymphocytic leukaemia. Br J Haematol. 2000;111(2):608- 617.
41. Goddard RV, Prentice AG, Copplestone JA, Kaminski ER. Generation in vitro of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate. Clin Exp Immunol. 2001;126(1):16-28.
42. Krackhardt AM, Harig S, Witzens M, Broderick R, Barrett P, Gribben JG. T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy. Blood. 2002;100(1):167- 173.
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