Page 206 - 2020_07-Haematologica-web

Ferrata Storti Foundation
Haematologica 2020 Volume 105(7):1948-1956
Platelet Biology & its Disorders
Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study
Francesco Paciullo,1 Loredana Bury,1 Patrizia Noris,2 Emanuela Falcinelli,1 Federica Melazzini,2 Sara Orsini,1 Carlo Zaninetti,2,3 Rezan Abdul-Kadir,4 Deborah Obeng-Tuudah,4 Paula G. Heller,5,6 Ana C. Glembotsky,5,6 Fabrizio Fabris,7 Jose Rivera,8 Maria Luisa Lozano,8 Nora Butta,9 Remi Favier,10 Ana Rosa Cid,11
Marc Fouassier,12 Gian Marco Podda,13 Cristina Santoro,14 Elvira Grandone,15,16 Yvonne Henskens,17 Paquita Nurden,8 Barbara Zieger,19 Adam Cuker,20
Katrien Devreese,21 Alberto Tosetto,22 Erica De Candia,23,24 Arnaud Dupuis,25
Koji Miyazaki,26 Maha Othman27 and Paolo Gresele1
1Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Italy; 2Department of Internal Medicine, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy; 3PhD program in Experimental Medicine, University of Pavia, Pavia, Italy; 4Haemophilia Centre and Haemostasis Unit, The Royal Free Foundation Hospital and University College London, London, UK; 5Hematología Investigación, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina; 6Universidad de Buenos Aires, Instituto de Investigaciones Médicas -IDIM-, Buenos Aires, Argentina; 7Clinica Medica 1 - Medicina Interna CLOPD, Dipartimento Assistenziale Integrato di Medicina, Azienda-Ospedale Università di Padova, Dipartimento di Medicina, Università di Padova, Padova, Italy; 8Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguery Centro Regional de Hemodonación, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain; 9Unidad de Hematología, Hospital Universitario La Paz-IDIPaz, Madrid, Spain; 10Assistance Publique-Hôpitaux de Paris, Armand Trousseau Children’s Hospital, French Reference Centre for Inherited Platelet Disorders, Paris, France; 11Unidad de Hemostasia y Trombosis, Hospital Universitario y Politecnico La Fe, Valencia, Spain; 12Consultations d'Hémostase – CRTH, CHU de Nantes, Nantes, France; 13Medicina III, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy; 14Hematology, Department of Translational and Precision Medicine, La Sapienza University of Rome, Rome, Italy; 15Unità di Ricerca in Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Foggia, Italy; 16Ob/Gyn Department of the First I.M. Sechenov Moscow State Medical University, Moscow, The Russian Federation; 17Hematological Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands; 18Reference Centre for Platelet Disorders, Bordeaux University Hospital Centre, Rythmology and Cardiac Modeling Institute (LIRYC), Xavier Arnozan Hospital, Pessac, France; 19Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center – University of Freiburg, Freiburg, Germany; 20Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 21Coagulation Laboratory, Department of Laboratory Medicine, Ghent University Hospital, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium; 22Hematology Department, S. Bortolo Hospital, Vicenza, Italy; 23Hemostasis and Thrombosis Unit, Insitute of Internal Medicine, Policlinico Agostino Gemelli Foundation, IRCCS, Rome, Italy; 24Institute of Internal Medicine and Geriatrics, Università Cattolica del Sacro Cuore, Rome, Italy; 25Université de Strasbourg, Institut National de la Santé et de la Recherche Médicale, Etablissement Français du Sang Grand Est, Unité Mixte de Recherche-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France; 26Department of Transfusion and Cell Transplantation Kitasato University School of Medicine, Sagamihara, Japan and 27Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada
ABSTRACT
Major surgery is associated with an increased risk of venous throm- boembolism (VTE), thus the application of mechanical or pharma- cologic prophylaxis is recommended. The incidence of VTE in patients with inherited platelet disorders (IPD) undergoing surgical proce- dures is unknown and no information on the current use and safety of
Correspondence:
PAOLO GRESELE
paolo.gresele@unipg.it
Received: May 28, 2019.
Accepted: September 25, 2019. Pre-published: September 26, 2019.
doi:10.3324/haematol.2019.227876
Check the online version for the most updated information on this article, online supplements, and information on authorship & disclosures: www.haematologica.org/content/105/7/1948
©2020 Ferrata Storti Foundation
Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or inter- nal use. Sharing published material for non-commercial pur- poses is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for com- mercial purposes is not allowed without permission in writing from the publisher.
1948
haematologica | 2020; 105(7)
ARTICLE