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Pre-treatment PET in advanced FL
patients treated with single agent rituximab, a trend for shorter PFS among patients treated with other frontline regimens and baseline SUVmax >18 was observed (77 months vs. not reached, P=0.17); of interest, in this group, only seven patients with baseline SUVmax >18 were evalu-
able for survival, likely limiting achievement of statistical significance.
Use of maintenance rituximab associated with a signifi- cantly longer PFS (not reached vs. 84 months, P<0.001); the association between use of maintenance rituximab
Table 1. Patient baseline characteristics and association with pre-treatment maximum standardized uptake value (SUVmax) >18.
Age
< 60 years
All patients (N=346)
199 (57) 147 (43)
157 (45) 189 (55)
286 (83)
60 (17)
165 (51) 161 (49)
288 (84)
56 (16)
Number (percentage) SUVmax < 18 (N=294)
168 (57) 126 (43)
140 (48) 154 (52)
245 (83)
49 (17)
148 (53) 129 (47)
255 (87)
37 (13)
SUVmax > 18 P (N=52)
31 (60) 0.76 21 (40)
17 (33) 0.05 35 (67)
41 (79) 0.43
11 (21)
17 (35) 0.02 32 (65)
≥ 60 years Female Male Hemoglobin
≥ 12 g/dL
< 12 g/dL
β2-microglobulin ≤ ULN
> ULN
LDH
≤ ULN
33 (63)
19 (37)
<0.001
> ULN
Grade 1-2
Ki-67
339 (99.5)
3A 3(0.5) 3(1) 0(0)
288 (99)
51 (100) 1
173 (86)
29 (14)
159 (47) 182 (53)
286 (83)
60 (17)
102 (29) 244 (71)
139 (42)
absent 203 (59)
present 143 (41)
FLIPI score
low 67 (19) Intermediate 137 (40)
high 142 (41)
FLIPI-2 score
low 29 (8) Intermediate 186 (54) high 131 (38)
147 (87)
22 (13)
134 (46) 157 (54)
252 (86)
42 (14)
87 (30) 207 (70)
114 (40)
175 (60)
119 (40)
56 (19) 123 (42) 115 (39)
26 (9) 163 (55) 105 (36)
26 (79) 0.28
7 (21)
25 (50) 0.65 25 (50)
< 40%
≥ 40%
Bone marrow not involved
involved
B-symptoms
absent
present
Ann Arbor Stage III
IV
Involved nodal areas
34 (65)
18 (35)
0.001
<5
15 (29) 1 37 (71)
25 (50) 0.22
≥5
193 (58) 179 (64)
168 (60) 163 (70)
25 (50)
16 (36) 28(64)
Largest lymph node
<6cm
≥6cm 99(36) 71(30)
<0.001
Extra-nodal disease
28 (54) 0.27
24 (46)
11 (21) 0.11 14 (27)
27 (52)
3 (6) 0.16 23 (44)
26 (50)
LDH: lactate dehydrogenase; ULN: upper limit of normal; FLIPI: follicular lymphoma international prognostic index; SUVmax: maximum standardized uptake value.
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