Page 31 - Haematologica - Vol. 105 n. 6 - June 2020

Geriatric assessment in older patients with a hematologic malignancy
Table 2. Comparison of impaired performance status with impairments in geriatric domains.
Author
Aguiar19
Corsetti20
Deschler21
Holmes22
Klepin23
Klepin24
Molga25,26
Umit27
Goede28
Molica29
Ribi30
Merli31 Ong32
Spina33 Tucci34 Tucci35
Aaldriks36
Naito37
Park38
Siegel39 Soubeyran40 Winkelmann41 Okuyama42 Engelhardt43 Gavriatopoulou44 Palumbo45 Rosko46
Wildes47
Zhong48
Buckstein49
Deschler50
Derman51
Dubruille52
Dumontier53
Hamaker54
Huang55 Lin56
Liu57
Muffly58 Nawas59 Rodrigues60 Rollot-Trad61 Silay62
Velghe63
Year Type of N Me(di)an
Poor ADL IADL Cognition Mood Physical Nutritional Social Poly- Frailty Summarised PS capacity status support pharmacy screening GA score
tool
- ---- 80% - - 61% 38% -
38% 17% 59% - - - - - - -
2020
2013 2013 2014 2013 2020 2020 2018 2016 2019 2017 2020 2019 2012 2009 2015
2015 2016 2015 2006 2011 2011 2015 2016 2019 2015 2019 2019 2017 2016 2018 2019 2015 2019 2016 2020 2020 2019 2014 2019 2020 2008 2015
2014
malignancy
MDS 76
AML;RAEB 31 AML;MDS 195 AML; MDS 50
AML 74 AML (FLT3) 40 AML; MDS 98
AML 372 CLL 75 CLL 108
B-cell lymphoma 41 DLBCL 33 DLBCL 205
DLBCL 100 DLBCL 84 DLBCL 173
NHL 44 NHL 93 NHL 70 NHL 25 NHL 32 NHL 143
Lymphoma; MM 106 MM 125 MM 110 MM 869 MM; amyloidosis 100
MM
MM
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
Various
age*
77 (70-84)
72(55-84) 71(60-87) 65 (60-73) 68 (65-74) 68 (61-83) 77 (66-95) 63 (19-97) 75 (48-87) 71 (65-90) 75 (40-94) 85 (68-89) 73 (60-97) 75 (70-89) 73 (66-89) 77
47% 34% 31% 9% 14% 12% 16% 16% 10% 22% 50% 41% 29% 40% ?????
54% 55% - - - - -
18% 36% 50% - 56% -
32% 31%
79% --
54% >28% - 66% - -- -
28% 29% 34% 11% 91% - 80% 14% ? - 19% 29%
27%
- - 68% - 70% -
- -
- 10% - 39% - -
- 38% - 13% - 50% - 38%
43% - - - 47% - - - - - - -
- 50%
? 36% - -
- -
- -
- - 7% - - - - - - - - - - -
- -
- -
- -
- -
- -
- -
- 17% - -
- -
- -
? - -- - 77% --
? 15% 6%
16% 19% - -- 27%
18% 3% -
- 48%
- - 20% - - - - - ? - - - - -
- - 15% - 21% - 16% 12% 94% -
-
- 73 % -
-
-
-
-
34% 51% 36% -
-
-
-
-
-
-
-
-
-
- 76% - 44% -
-
-
-
-
-
- 43%
7% 7% 36% -
26% 27% 31% ?
? 12% - -
? >4%; >9%; -
27% 4% - 37% - 0%
81% 38% 21% - 45% 23% 85% -
6%
22% 28% 39% - 12% - 41% 59% 16% 18% 29% 33% 28% 48%
<54% <54% -- 5%
78 (70-86)
77 (65-90)
74 (65-92)
70 (60-85)
79(70-92)
63(18-88)
74(65-90)
63(56-71)
83 (80-92)
74(70-78)
59 (36-75)
71 (66-76)
58 (52-66 ) ? 67% 71(65-79) 7% - 66(60-78) 60% 9%
>67(60-83) <50% - 90 74(65-89) 32% 11% 464 80 (76-84) ? 11% 157 78(67-99) 42% 22%
- - 30% - - - >60% 18% 42% - - -
- - 73% -
21% 14%
48% ? ? ?
- - 19% 7% ? 40%
18% -
- 30%
40 628 445 106 192
40% -
63% 10%
55% -
45% - - 39%
- -
- -
- -
- - - -
? 54% - -
- 50% 72% 80% - - - -
20% 66% - 71% ? 50% - -
- 50% - - -- - 53% -- - 25% ?- - -
- 64% 25% -
31%
40%
39%
27%
47%
39% 1%
12% - 3% 7% 22% - 31% 25% 4%
? - - 18% 29% 30% 44% 8%
148 62 (50-76) 28%-
457 66(60-79)<47%4%11% 44%18% - 448 80(76-84) 47% - - 18% - 56%
203 58 (54-63) 29 % 7 % 184 61 (50-75) 1 % -
40% - - 24% 36% 3% 35% 15%
40 68(60-76) 75% - 10% 54 86(75-99) 56% 39% 51% 61 69 ?21% 26%
50 76 (70-87) ? 24 %
21% 18% 16%
27% - - - - 26% 34% 16% 27% -
-
38% 4% 30% - 82% -- 76% 88%
80% - 19% 39% - - 51% - -
*Reported as mean (± standard deviation) or median (range or interquartile range)? Although geriatric condition was assessed, the proportion of patients with geriatric impairments could not be extracted from the published data. PS: World Health Organization performance status; ADL: activities of daily living; IADL: instrumental activities of daily living; GA: geriatric assessment; MDS: myelodysplastic syndrome; AML: acute myeloid leukemia; RAEB: refractory anemia with excess of blasts; FLT3: FMS-like tyrosine kinase-3; CLL: chronic lymphocytic leukemia; DLBCL: diffuse large B-cell lymphoma; NHL: non-Hodgkin lymphoma; MM: multiple myeloma.
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