Page 113 - Haematologica May 2020
P. 113

BCR-FGFR1 regulated by dimerization and chaperonin Hsp90
    blocks ETV6-NTRK3-induced cellular trans- formation. J Biol Chem. 2013;288(39):27940- 27950.
23. Taylor CM, Keating AE. Orientation and oligomerization specificity of the Bcr coiled- coil oligomerization domain. Biochemistry. 2005;44(49):16246-16256.
24. Zhao X, Ghaffari S, Lodish H, et al. Structure of the Bcr-Abl oncoprotein oligomerization domain. Nat Struct Biol. 2002;9(2):117-120.
25. Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605-1612.
26. Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol. 2010;11(7):515-528.
27. Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005;5(10):761-772.
28. Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med. 2002;8(4 Suppl):S55-61.
29. Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960;25:85- 109.
30. Nambiar M, Kari V, Raghavan SC. Chromosomal translocations in cancer. Biochim Biophys Acta. 2008;1786(2):139- 152.
31. Musumeci F, Greco C, Grossi G, et al. Recent studies on ponatinib in cancers other than chronic myeloid leukemia. Cancers (Basel). 2018;10(11).
32. Gvritishvili AG, Gribenko AV, Makhatadze GI. Cooperativity of complex salt bridges. Protein Sci. 2008;17(7):1285-1290.
33. Jin Y, Zhen Y, Haugsten EM, Wiedlocha A. The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90
addicted oncoprotein. Cell Signal. 2011;
23(11):1758-1766.
34. Gallo LH, Ko J, Donoghue DJ. The impor-
tance of regulatory ubiquitination in cancer and metastasis. Cell Cycle. 2017;16(7):634- 648.
35. Hu T, Wu Q, Chong Y, et al. FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lym- phoma syndrome. Leukemia. 2018;32(11): 2363-2373.
36. HuT,ChongY,LuS,etal.LossoftheBCR- FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B- Lymphomagenesis in Mice. Cancer Res. 2019;79(1):114-124.
37. Bhatia S, Diedrich D, Frieg B, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response. Blood. 2018; 132(3):307-320.
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