Page 94 - Haematologica April 2020

Y. Xie et al.
hereditary hemolytic anemia. Blood. 1995;
85(1):250–256.
16. Yawata Y, Kanzaki A, Yawata A, Doerfler
W, Ozcan R, Eber SW. Characteristic features of the genotype and phenotype of hereditary spherocytosis in the Japanese population. Int J Hematol. 2000;71(2):118-135.
17. Satyanarayana A, Gudmundsson KO, Chen X, et al. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010;116(16):2921– 2931.
18. Kourlas PJ, Strout MP, Becknell B, et al. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evi- dence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2000;97(5):2145–2150.
19. Drenberg C, Hu S, Li L, et al. ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression. Clin Transl Sci. 2016;9(1):51–59.
20. Yang L, Wang L, Kalfa TA, et al. Cdc42 criti- cally regulates the balance between myelopoiesis and erythropoiesis. Blood. 2007;110(12):3853-3861.
21. Ghiaur G, Lee A, Bailey J, JA C, Zheng Y, DA W. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progeni- tor cell proliferation and engraftment. Blood. 2006;108(6):2087–2094.
22. Sankaran VG, Ghazvinian R, Do R, et al. Exome sequencing identifies GATA1 muta- tions resulting in Diamond-Blackfan anemia. J Clin Invest. 2012;122(7):2439-2443.
23. van Lochem EG, van der Velden VHJ, Wind HK, te Marvelde JG, Westerdaal NAC, van Dongen JJM. Immunophenotypic differenti- ation patterns of normal hematopoiesis in human bone marrow: Reference patterns for age-related changes and disease-induced shifts. Cytometry. 2004;60B(1):1–13.
24. Orkin SH and Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631–644.
25. Paffett-Lugassy NN, Zon LI. Analysis of hematopoietic development in the zebrafish. Methods Mol Med. 2005;105: 171–198.
26. Reuther GW, Lambert QT, Booden MA, et al. Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes
Transformation by Activation of RhoA. J
Biol Chem. 2001;276(29):27145–27151.
27. Salasvidal E, Meijer AH, Cheng X, Spaink HP. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial
infection. Genomics. 2005;86(1):25–37.
28. Qiu RG, Chen J, Mccormick F, Symons M. A Role for Rho in Ras Transformation. Proc Natl Acad Sci U S A. 1995;92(25):11781–
11785.
29. Dvorsky R, Ahmadian MR. Always look on
the bright site of Rho: structural implications for a conserved intermolecular interface. EMBO Rep. 2004;5(12):1130–1136.
30. Perez OD, Mitchell D, Campos R, Gao GJ, Li L, Nolan GP. Multiparameter analysis of intracellular phosphoepitopes in immunophenotyped cell populations by flow cytometry. Curr Protoc Cytom. 2005;Chapter 6:Unit 6.20.
31. Ahlgren J, Patel N, Simmens S, et al. O-MAX chemotherapy: high activity in metastatic esophagogastric adenocarcinoma and possi- ble relation to subclinical hemolysis. Oncology. 2014;87(6):371–380.
32. Betensky M, Witmer C, Fisher MJ, Nance S, Weiss MJ, Sesok-Pizzini DA. Immune hemolytic anemia with drug-induced anti- bodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. Transfusion. 2015;54(11):2901– 2905.
33. Lang E, Bissinger R, Qadri SM, Lang F. Suicidal death of erythrocytes in cancer and its chemotherapy: A potential target in the treatment of tumor-associated anemia. Int J Cancer. 2017;141(8):1522–1528.
34. Lang E, Lang PA, Shumilina E, et al. Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7. Pflugers Arch. 2010;460(3):667–676.
35. Abiko H, Fujiwara S, Ohashi K, et al. Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorien- tation of vascular endothelial cells. J Cell Sci. 2015;128(9):1683-1695.
36. Thompson WR, Yen SS, Uzer G, et al. LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage. Bone. 2018;107:172–180.
37. Shi GX, Yang WS, Jin L, Matter ML, Ramos JW. RSK2 drives cell motility by serine phos-
phorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 2018;115(2):E190–E199.
38. Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW. Leukemia- associated Rho guanine-nucleotide exchange factor is not critical for RhoA reg- ulation, yet is important for platelet activa- tion and thrombosis in mice. J Thromb Haemost. 2015;13(11):2102–2107.
39. Hua WK, Chang YI, Yao CL, Hwang SM, Chang CY, Lin WJ. Protein Arginine Methyltransferase 1 Interacts with and Activates p38α to Facilitate Erythroid Differentiation. PLoS One. 2013;8(3): e56715.
40. Shahab U, Jeong AK, Jodie U, Dolores M, Amittha W. Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells. Proc Natl Acad Sci U S A. 2004;101(1): 147–152.
41. Pace BS, Qian XH, Sangerman J, et al. p38 MAP kinase activation mediates γ-globin gene induction in erythroid progenitors. Exp Hematol. 2003;31(11):1089–1096.
42. Schultze SM, Mairhofer A, Li D, et al. p38α controls erythroblast enucleation and Rb sig- naling in stress erythropoiesis. Cell Res. 2012;22(3):539–550.
43. Hanenberg H, Filippi M-D, Ivan M, et al. P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim. Nat Commun. 2018;9 (1):3518.
44. Bulavin DV, Saito S, Hollander MC, et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphoryla- tion and apoptosis in response to UV radia- tion. Embo J. 1999;18(23):6845–6854.
45. Kuhnel B, Aspelund T, Yang Q, et al. Multiple loci influence erythrocyte pheno- types in the CHARGE Consortium. Nat Genet. 2009;41(11):1191–1198.
46. Kamatani Y, Matsuda K, Okada Y, et al. Genome-wide association study of hemato- logical and biochemical traits in a Japanese population. Nat Publ Gr. 2010;42(3):210–215.
47. Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH, Freson K. Silencing of RhoA nucleotide exchange fac- tor , ARHGEF3, reveals its unexpected role in iron uptake. Blood. 2011;118(18):4967– 4977.
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