Page 137 - Haematologica March 2020
P. 137

Iron chelation in lower risk MDS patients
decreased quality of life and reduced over- all survival. Blood, annual meeting abstracts. 2018;132(S1):abstract 4392.
33. Wermke M, Eckholdt J, Götze KS, et al. Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodys- plastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): a prospective, multicentre, obser- vational trial. Lancet Haematol. 2018; 5:e201-210.
34. Hershko C, Link G, Cabantchik I. Pathophysiology of iron overload. Ann N Y Acad Sci. 1998;850:191-201.
35. Pilo F, Angelucci E. A storm in the niche: Iron, oxidative stress and haemopoiesis. Blood Rev. 2018;32(1):29-35.
36. Taher AT, Saliba AN, Kuo KH, et al. Safety
and Pharmacokinetics of the Oral Iron Chelator SP-420 in β-thalassemia. Am J Hematol. 2017;92(12):1356-1361.
37. Hartmann J, Braulke F, Sinziq U, et al. Iron overload impairs proliferation of erythroid progenitors cells (BFU-E) from patients with myelodysplastic syndromes. Leuk Res. 2013;37(3):327-332.
38. Cazzola M, Della Porta MG, Malcovati L. Clinical relevance of anemia and transfu- sion iron overload in myelodysplastic syn- dromes. Hematology Am Soc Hematol Educ Program. 2008:166-175.
39. Malcovati L, Porta MG, Pascutto C, et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clin- ical decision making. J Clin Oncol. 2005;
23(30):7594-7603.
40. Greenberg PL, Attar E, Bennett JM, et al.
NCCN Clinical Practice Guidelines in Oncology: myelodysplastic syndromes. J Natl Compr Canc Netw. 2011;9(1):30-56.
41. Pimková K, ChrastinováL, Suttnar J, et al. Plasma levels of aminothiols, nitrite, nitrate, and malondialdehyde in myelodys- plastic syndromes in the context of clinical outcomes and as a consequence of iron overload. Oxid Med Cell Longev. 2014 Jan; DOI 10.1155/2014/416028.
42. de Souza GF, Barbosa MC, Santos TE, et al. Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syn- dromes. J Clin Pathol. 2013;66(11):996- 998.
haematologica | 2020; 105(3)
651


































































































   135   136   137   138   139