Page 236 - 2020_02-Haematologica-web

M.-V. Mateos et al.
Table 1. Baseline and demographic characteristics.
65-74 years
≥75 years
78.0 (75-87)
21 (60.0)
14 (40.0)
21 (60.0) 4 (11.4) 2 (5.7) 0
8 (22.9)
11 (31.4) 21 (60.0) 3 (8.6)
12 (34.3) 11 (31.4) 12 (34.3)
4.0 (0.8-14.6)
16 (45.7) 8 (22.9) 10 (28.6) 1 (2.9)
Characteristic: POLLUX
Age (years) Median (range)
Sex, n (%)
Male
Female Race, n (%)a
White
Asian
Black or African American Unknown
Not reported
Baseline ECOG score, n (%)
0 1 2
ISS staging, n (%)b I
II
III
Time from diagnosis, years
Median (range)
Prior lines of therapy, n (%)
1 2 3 >3
Cytogenetic profile, n (%)c
N Standard High
Characteristic: CASTOR
Age (years) Median (range)
Gender, n (%)
Male
Female Race, n (%)a
White
Black or African American
Asian
American Indian or Alaska Native
Other 2(2.1) 0 1(4.3) 0
D-Rd (n=124)
69.0 (65-74)
83 (66.9)
41 (33.1)
95 (76.6) 18 (14.5) 2 (1.6) 0
9 (7.3)
60 (48.4) 60 (48.4) 4 (3.2)
51 (41.1) 42 (33.9) 31 (25.0)
3.8 (0.4-22.5)
62 (50.0) 36 (29.0) 19 (15.3) 7 (5.6)
Rd (n=108)
69.0 (65-74)
62 (57.4)
46 (42.6)
72 (66.7) 19 (17.6) 3 (2.8) 1 (0.9) 13 (12.0)
54 (50.0) 46 (42.6) 8 (7.4)
57 (52.8) 31 (28.7) 20 (18.5)
3.6 (0.4-18.3)
59 (54.6) 31 (28.7) 11 (10.2) 7 (6.5)
D-Rd (n=29)
77.0 (75-89)
14 (48.3)
15 (51.7)
19 (65.5) 6 (20.7) 1 (3.4) 1 (3.4) 2 (6.9)
10 (34.5) 15 (51.7) 4 (13.8)
10 (34.5) 13 (44.8) 6 (20.7)
2.6 (0.8-27.0)
17 (58.6) 7 (24.1) 3 (10.3) 2 (6.9)
Rd (n=35)
67 57 13 16
56 (83.6)
11 (16.4)
D-Vd (n=96)
69.0 (65-74)
53 (55.2)
43 (44.8)
44 (77.2)
13 (22.8)
Vd (n=87)
69.0 (65-74)
53 (60.9)
34 (39.1)
10 (76.9)
3 (23.1)
D-Vd (n=23)
78.0 (75-88)
13 (56.5)
10 (43.5)
12 (75.0)
4 (25.0)
Vd (n=35)
78.0 (75-85)
20 (57.1)
15 (42.9)
Unknown
Not reported
Baseline ECOG score, n (%)
0 1 2
0 0
39 (40.6) 51 (53.1) 6 (6.3)
0
3 (3.4)
38 (43.7) 39 (44.8) 10 (11.5)
0 0
6 (26.1) 17 (73.9) 0
1 (2.9) 2 (5.7)
16 (45.7) 17 (48.6) 2 (5.7)
83 (86.5) 6 (6.3) 4 (4.2) 1 (1.0)
81 (93.1) 1 (1.1) 2 (2.3) 0
22 (95.7) 0
0
0
29 (82.9) 1 (2.9) 2 (5.7) 0
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haematologica | 2020; 105(2)