Page 14 - 2020_02-Haematologica-web

Editorials
ior colleague once told me after I had told him that I worked on aging – “Hurry up”.
References
1. Kenyon CJ. The genetics of ageing. Nature. 2010;464(7288):504-512.
2. Yuan R, Peters LL, Paigen B. Mice as a mammalian model for
research on the genetics of aging. ILAR J. 2011;52(1):4-15.
3. de Haan G, Bystrykh LV, Weersing E, et al. A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic
cell turnover. Blood. 2002;100(6):2056-2062.
4. Brown A, Schuetz D, Han Y, et al. The lifespan quantitative trait
locus gene Securin controls hematopoietic progenitor cell function.
Haematologica. 2019;105(2):317-324.
5. Schollaert KL, Poisson JM, Searle JS, Schwanekamp JA, Tomlinson
CR, Sanchez Y. A role for Saccharomyces cerevisiae Chk1p in the
response to replication blocks. Mol Biol Cell. 2004;15(9):4051-4063.
6. HsuYH,LiaoLJ,YuCH,etal.Overexpressionofthepituitarytumor transforming gene induces p53-dependent senescence through acti- vating DNA damage response pathway in normal human fibrob-
lasts. J Biol Chem. 2010;285(29):22630-22638.
7. Forsti A, Frank C, Smolkova B, et al. Genetic variation in the major
mitotic checkpoint genes associated with chromosomal aberrations
in healthy humans. Cancer Lett. 2016;380(2):442-446.
8. Zhang L, Vijg J. Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging. Annu Rev Genet.
2018;52:397-419.
9. Prud'homme B, Gompel N, Carroll SB. Emerging principles of regu-
latory evolution. Proc Natl Acad Sci U S A. 2007;104(suppl 1):8605-
8612.
10. Horvath S, Raj K. DNA methylation-based biomarkers and the epi-
genetic clock theory of ageing. Nat Rev Genet. 2018;19(6):371-384.
11. Han Y, Eipel M, Franzen J, et al. Epigenetic age-predictor for mice
based on three CpG sites. Elife. 2018;7.
12. BallARJr,ChenY-Y,YokomoriK.Mechanismsofcohesin-mediated
gene regulation and lessons learned from cohesinopathies. Biochim
Biophys Acta. 2014;1839(3):191-202.
13. Kirkwood TB. Understanding the odd science of aging. Cell.
2005;120(4):437-447.
14. Williams GC. Pleiotropy, Natural Selection, and the Evolution of
Senescence. Evolution. 1957;11:398-411
15. van Heemst D. Insulin, IGF-1 and longevity. Aging Dis.
2010;1(2):147-157.
16. Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in
immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev. 2005;126(2):351-361.
248
haematologica | 2020; 105(3)