Page 176 - Haematologica Atlas of Hematologic Cytology

Besides cutaneous T-cell T-cell lymphoma lymphoma also the the other types of peripheral T-cell T-cell lymphomas may show a a a a a a a leukemic picture at at at presentation although this is is rare In particular in in anaplastic large cell lymphoma circulating and bone marrow infiltrating cells may be enormous in in in size Table 2 ytological features of mature T T and natural iller ( ) cell leu emias Cell
Size
hroma n ucleolus
ytoplasm
ther features Large granular lymphocyte
>2 RBCs
Clumped
Absent
Abundant clear
Cytoplasmic azurophilic granules
Prolymphocyte
>2 RBCs
Clumped
One almost invisible
Scanty
Irregular nuclear border
TLL cell >2 RBCs
Clumped
Absent
Rather scanty
Mul lobated nucleus
S zary syndrome cell >2 RBCs
Clumped
Absent
Scanty
Cerebriform nucleus
RBCs: red blood cells ATLL: adult T-cell leukemia/lymphoma Table 3 Immunophenotypic features of mature T T and natural iller ( ) cell leu emias Mar er LGL
ggressive PLL ATLL S zary syndrome CD2
+ + + + + CD3 + +c
+ + + CD5
- - + + + CD7
- - + - - CD4 - - + + + CD8 + -/+
-/+
- - CD25
- - - + - CD56
- + - - - CD16
+ - - - - TIA1
+ + - - - r r Per + + - - - : : : : : : : >90% of of of of cases cases cases cases are are are are posi posi posi posi ve ve ve ve ve ve /-: >50% of of of of cases cases cases cases are are are are posi posi posi posi ve ve ve ve ve ve -/ : : : : : : : <50% of of of of cases cases cases cases are are are are posi posi posi posi ve ve ve ve ve ve -: -: <10% of of of of cases cases cases cases are are are are posi posi posi posi ve ve ve ve ve ve LGL: large granular lymphocy lymphocy c c c c c c c c c c c c c leukemia leukemia leukemia leukemia Aggressive NK: aggressive NK-cell leukemia leukemia leukemia leukemia PLL: prolymphocy c c c c c c c c c c c c c leukemia leukemia leukemia leukemia ATLL: adult T-cell leukemia/lymphoma c: cytoplasmic only GrB: granzyme B B Per: perforin Reference
Swerdlow SH Campo E Pileri SA et al al The 2016 2016 revision of of the World Health Organiza on on on classi ca on on on of of lymphoid neoplasms
Blood 2016 2016 127(20):2375-2390 163