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New drugs in MM with EMD
Table 2. Patients’ demographics and clinical characteristics.
Characteristic
Age
Median (IQR)-yr Distribution – n. (%) <65 yr
65to75
≥75
ECOG
Patients with extra-medullary disease (N=267)
68 (60-74)
108 (40%) 105 (39%) 54 (21%)
Control group P (N=2065)
69 (61-74) 0.21
477 (38%) 795 (38%) 493 (24%)
0
1
2
3 1(0%) 7(0%)
107 (40%) 103 (39%) 39 (15%)
847 (41%) 0.35 862 (42%)
235 (11%)
ISS I II
III missing
R-ISS
I
II
III missing
FISH – n. (%) Standard risk High risk*
del(17p) t(4;14) t(14;16)
Missing
119 (45%) 85 (32%) 38 (14%) 25 (9%)
38 (14%) 125 (47%) 17 (6%) 87 (33%)
115 (43%) 51 (19%) 32
22
6
101 (38%)
201 (75%) 29 (11%) 37 (14%)
682 (33%) 782 (38%) 509 (25%) 92 (4%)
<0.001
294 (14%) 0.62 1132 (55%)
LDH – IU/L
173 (8%)
466 (23%)
1082 (52%) 446 (22%) 220 219
69
537 (26%)
1567 (76%) 180 (9%) 318 (15%) 50%(30%-70%) 10.7 (9.5 – 12.1)
66 (41-88) 359 (17%) 544 (26%) 1162 (56%)
1279 (62%) 464 (22%) 322 (16%)
0.72
0.30
<0.001 <0.001 0.01
0.48
≤450 201 >450 201 missing
Bonemarrowplasmacells,median(IQR) 30%(15%-50%)
Hemoglobin, median (IQR) – gr/L
Creatinine clearance
Median (IQR) – mL/min per 1.73/m2 < 30 mL/min per 1.73/m2
30 to 60 mL/min per 1.73/m2
> 60 mL/min per 1.73/m2
Therapy
IMiD-based PI-based
IMiD + PI-based
Autologous stem cell transplantation Fixed-duration therapy
Continuous treatment
No maintenance
Imaging technique
X-ray skeletal survey
CT-scan
MRI 115(43%)
12.0 (10.5 – 13.6)
75 (48-98) 45 (17%) 49 (18%) 172 (64%)
166 (62%) 66 (25%) 35 (13%) 155 (58%) 31 (12%) 128 (48%) 108 (40%)
1283 (62%) 0.17 243 (12%) 1.00
Physical examination Spiral CT Conventional CT Unknown
21 (8 %) 13 (5%) 96 (36%) 22 (8%)
0 (0 %) 0 (0 %)
1007 (49%) 815 (39%)
989 (42%) 277 (13 %) 0(0%) 0 (0%)
2 (0%) 675 (33%) 122 (6 %)
<0.001
*More than one fluorescence in situ hybridization (FISH) abnormality may occur in the same patient. NS: not significant; NA: not assessable; IQR: interquartile range; IMiD: immunomodulatory drug; PI: proteasome inhibitor; CT: computed tomography; MRI: magnetic resonance imaging. ECOG: Eastern Cooperative Oncology Group.
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