Page 202 - 2020_01-Haematologica-web

R.W.J. Meijers et al.
lymphocytic leukemia B cells. J Immunol.
2000;164(4):2200-2206.
29. Cuni S, Perez-Aciego P, Perez-Chacon G, et
al. A sustained activation of PI3K/NF- kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia. 2004;18(8):1391-1400.
30. Yu M, Chen Y, He Y, et al. Critical role of B cell lymphoma 10 in BAFF-regulated NF- kappaB activation and survival of anergic B cells. J Immunol. 2012;189(11):5185-5193.
31. Gasparini C, Celeghini C, Monasta L, Zauli G. NF-kappaB pathways in hematological malignancies. Cell Mol Life Sci. 2014;71(11):2083-2102.
32. Alves BN, Tsui R, Almaden J, et al. IkappaBepsilon is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific man- ner. J Immunol. 2014;192(7):3121-3132.
33. Domenech E, Gomez-Lopez G, Gzlez-Pena D, et al. New mutations in chronic lympho- cytic leukemia identified by target enrich-
ment and deep sequencing. PLoS One.
2012;7(6):e38158.
34. Mansouri L, Noerenberg D, Young E, et al.
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood. 2016;128(23): 2666-2670.
35. Feuerhake F, Kutok JL, Monti S, et al. NFkappaB activity, function, and target- gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B- cell lymphoma subtypes. Blood. 2005;106(4):1392-1399.
36. Foa R, Massaia M, Cardona S, et al. Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease. Blood. 1990;76(2):393-400.
37. Das T, Chen Z, Hendriks RW, Kool M. A20/tumor necrosis factor alpha-induced protein 3 in immune cells controls develop- ment of autoinflammation and autoimmu-
nity: lessons from mouse models. Front
Immunol. 2018;9:104.
38. Chu Y, Vahl JC, Kumar D, et al. B cells lack-
ing the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyper- activation and cause inflammation and autoimmunity in aged mice. Blood. 2011;117(7):2227-2236.
39. Frenzel LP, Claus R, Plume N, et al. Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus. Int J Cancer. 2011;128(10):2495-2500.
40. Nechanitzky R, Akbas D, Scherer S, et al. Transcription factor EBF1 is essential for the maintenance of B cell identity and pre- vention of alternative fates in committed cells. Nat Immunol. 2013;14(8):867-875.
41. Seifert M, Sellmann L, Bloehdorn J, et al. Cellular origin and pathophysiology of chronic lymphocytic leukemia. J Exp Med. 2012;209(12):2183-2198.
192
haematologica | 2020; 105(1)