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A. Dupont et al.
speculative point requires further investigation.
In conclusion, elevated levels of desialylation are observed in patients with type 2B vWD and mice carrying the p.V1316M mutation. The desialylation primarily con- cerns N-glycans and does not involve GPIba or GPVI but involved aIIb and β3 integrins. Although desialylation was observed under baseline conditions, it does not appear to be an important contributor to thrombocytope-
Acknowledgments
The authors wish to thank Edith Fressinaud for her expertise in the area of vWF. We also thank the patients who participated in the study.
Funding
This study was funded by grants from the INSERM, Force Hémato/Groupe GFHT (to AK) and the Agence Nationale de la Recherche (ANR 11 BSV1-010-01, to CVD).
nia in type 2B vWD.
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