Page 92 - 2019_06-Haematologica-web

F. Baron et al.
Table 3. Association between monosomal karyotype and Medical Research Council adverse-risk group and overall survival.
Table 4. Association between monosomal karyotype and Medical Research Council adverse-risk group and overall survival from com- plete remission with or without hematologic recovery.
Covariate
Cytogenetic group NotAdvMK- AdvMK-
MK+
Cytogenetic group NotAdvMK- AdvMK-
MK+
Age (years) 15-25
26-45
46-60
HR 95% CI
Unadjusted analysis^
1
1.48 1.26-1.74 2.58 2.19-3.04
Multivariate analysis*
P value <0.001
<0.001
<0.001
<0.001
<0.001
Covariate
HR 95% CI
Unadjusted analysis^
P value
<0.001
<0.001
<0.001
0.004
0.069
1 1.51 2.71
1 1.05 1.44
1.28-1.77 2.29-3.20
0.86-1.29
1.18-1.75
0.97-1.23 1.50-2.07
0.95-1.22
1.20-1.68
1 1.52 2.95
- 1.23-1.88 2.32-3.74
0.82-1.35
1.15-1.86
0.92-1.23 1.16-1.78
0.85-1.17
1.03-1.64
Cytogenetic group
NotAdvMK- 1
AdvMK- MK+
Cytogenetic group NotAdvMK- AdvMK-
MK+
1.50 1.22-1.85 2.87 2.27-3.63
Multivariate analysis*
Age (years)
15-25 1
WHO Performance Status at baseline 01
1 1.09 2-4 1.76
1.08
1.42
26-45
46-60
1.05
1.46
WBC at diagnosis (x109/L)
<25 1
1 2-4
1.06 1.43
≥ 25 and < 100
WBC at diagnosis (x109/L)
<25 1
WHO Performance Status at baseline 01
≥ 100
≥ 25 and < 100
1.00
1.30
HR: hazard ratio; 95% CI: 95% confidence interval; NotAdvMK–: not adverse cytogenet- ic excluding a monosomal karyotype; AdvMK–: adverse cytogenetic excluding a monosomal karyotype;MK+:monosomal karyotype;WHO:World Health Organization; WBC: white blood cell count. ^Obtained with a logistic regression model including protocol (AML-10 vs.AML-12) and cytogenetic group.*Obtained with a logistic regres- sion model including protocol and all covariates presented in the Table.
A
≥ 100
HR: hazard ratio; 95% CI: 95% confidence interval; NotAdvMK–: not adverse cytogenet- ic excluding a monosomal karyotype; AdvMK–: adverse cytogenetic excluding a monosomal karyotype;MK+:monosomal karyotype;WHO:World Health Organization; WBC: white blood cell count. ^Obtained with a logistic regression model including protocol (AML-10 vs.AML-12) and cytogenetic group.*Obtained with a logistic regres- sion model including protocol and all covariates presented in the Table.
B
Figure 3. Impact of allogeneic hematopoietic stem cell trans- plantation in patients with a monosomal karyotype. (A) Overall survival from complete remis- sion/complete remission with incomplete blood count recovery according to donor availability among patients with a monoso- mal karyotype. (B) Overall survival from hematopoietic stem cell transplantation by type of trans- plant among patients with a monosomal karyotype. HR: hazard ratio; 95% CI: 95% confidence interval; CR/Cri: complete remis- sion/complete remission with incomplete blood count recovery; HSCT: hematopoietic stem cell transplantation; Auto-; autologous; RD allo-: related donor allogeneic.
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