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Z. Wu et al.
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Figure 5. Dynamically expressed long noncoding RNAs in differentiation. Expression of sequentially upregulated/downregulated messenger RNAs (mRNAs) (left) and long noncoding RNAs (lncRNAs) (right) from HSC to MEP (A), and to GMP/ProB/ETP (B). MEP downregulated genes (red), MEP upregulated genes (pink), GM/L down- regulated genes (orange), and GM/L upregulated genes (blue). (C) A network of commonly downregulated mRNAs and lncRNAs in NRF2, IL-6, HIF1, ATF2, and AP1 signaling pathways. (D) A network of mRNAs and lncRNAs specifically upregulated in MEP in hemoglobin synthesis and androgen signaling pathways (left); and a net- work of mRNAs and lncRNAs specifically upregulated in GM/L in B-cell, T-cell, and integrin signaling pathways (right). HSC: hematopoietic stem cell; MLP: multilym- phoid progenitor; MEP: megakaryocyte-erythroid progenitor; GMP: granulocyte-monocyte progenitor, ProB: pro-B cell; ETP: earliest thymic progenitor; GM/L: granulo- cyte/monocyte/lymphocyte progenitor.
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haematologica | 2019; 104(5)