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K.T. Prochazka et al.
Figure 2. Concurrent gene mutations in 98 TP53-mutated cases of acute myeloid leukemia divided by functional classes. Of those speci- mens with two or more TP53 mutations, only the one with the highest vari- ant allele frequency (VAF) is listed. Each col- umn represents an indi- vidual patient with the total number of cooper- ating events stated at the bottom. Each colored box represents a muta- tion of the gene listed at the left. The red vertical lines indicate the 40% and 20% cut-offs with respect to TP53 VAF. #: number.
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Figure 3. Kaplan-Meier analysis of overall survival in 1,537 patients with acute myeloid leukemia stratified by TP53 mutational status. (A) Overall survival: TP53 wild-type patients versus TP53-mutated patients. (B) Overall survival: TP53 wild-type patients versus patients in the three groups with the defined variant allele fre- quencies of mutated TP53.
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haematologica | 2019; 104(3)