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HB9 induces senescence
tion t(7;12) AML.50 Thus, whole exome or whole genome analysis is necessary to identify additional relevant muta- tions in translocation t(7;12) AML.
In summary, the induction of premature senescence, together with perturbed hematopoietic differentiation, for the first time, sheds light on the oncogenic properties of HB9 in translocation t(7;12) AML. This will help us to find novel approaches for the treatment of fatal translocation t(7;12) AML, especially because resistance to therapy is a hallmark of this AML subtype.
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Funding
JH has been supported by the German Cancer Aid (110997), the German José Carreras Leukemia Foundation (DJCLS 02R/2016), the Deutsche Kinderkrebsstiftung (DKS 2016.17) and the “Forschungskommission” of the medical faculty of Heinrich-Heine-University.
Acknowledgments
We are indebted to all members of our group for useful discus- sions and critical reading of the manuscript. We thank Silke Furlan for excellent technical support.
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