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HLA-DP-restricted cell-lineage recognition patterns
A
B
C
D a representative HLA- DPB1*03:01-restricted T-cell clone (derived from response 4) when stimulated with primary acute myeloid leukemic blasts but not when stimulated with other primary malignant cells or (D) other non-hematopoietic cells. This recognition pattern was seen for the tested T-cell clones of response 2 (n=3), response 4 (n=6) and response 5a (n=3). The number between brackets indicates the individ- ual from whom the stimulator cells were derived. AML: acute myeloid leukemia; B-ALL: B-cell acute lymphoblastic leukemia; CLL: chronic lymphocytic
Figure 3. Differential recogni- tion of primary malignant and non-hematopoietic cells by allo- HLA-DP-specific T cells. (A) Interferon-gamma (IFNγ) pro- duction by a representative HLA-DPB1*03:01-restricted T- cell clone (derived from response 4) when stimulated with a variety of primary malig- nant cells and (B) not when stimulated with non-hematopoi- etic tissue cell lines. This recog- nition pattern was seen for the tested T-cell clones of response 2 (n=3), response 3 (n=3), response 4 (n=1) and response 5a (n=5). (C) IFNγ production by
leukemia.
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