Page 144 - 2018_11-Haematologica-web

M. Solans et al.
Table 1. Baseline characteristics of chronic lymphocytic leukemia for cases and controls in the multicase-control (MCC-Spain) study.
Western, mean (SD)
Prudent, mean (SD) Mediterranean, mean (SD) Province, n(%)
Barcelona Asturias Cantabria Granada Girona
Age (years), mean (SD)
Sex, n(%) Male Female
Energy intake (kcal/day), mean (SD)
Current alcohol intake (g/day), median (IQI)2 BMI (kg/m2), mean (SD)2
Height (cm), mean(SD)2
Waist-to-hip ratio3, n(%)
Low Moderate High Unknown
Smoking status, n(%)
Never Former Current Unknown
Education, n(%)
No formal education Primary
Secondary University
Physical activity4, n(%)
Inactive Low Moderate Very active Unknown
Ever worked in farming or agriculture, n(%) No
Yes
Unknown
Family history of hematologic malignancy, n(%)
No
Yes
Rai stage
Controls (n=1605)
5.88 (1.46)
6.55 (1.12) 7.08 (1.00)
900 (56) 211 (13) 281 (18) 144 (9) 69 (4) 64.30 (10.54)
936 (58)
669 (42) 1901.15 (585.88) 8.80 (0.58;27.32) 26.99 (4.50) 165.63 (8.51)
460 (29) 449 (28) 682 (42) 14 (1)
696 (43) 602 (38) 303 (19) 4 (0)
357 (22) 502 (31) 461 (29) 285 (18)
656 (41) 219 (14) 190 (12) 502 (31) 38 (2)
1257 (78) 323 (20) 25 (2)
1551 (97)
54 (3)
Cases P1 (n=369)
6.06 (1.40) 0.03
6.66 (1.03) 0.07 7.16 (0.88) 0.20
242 (66) 51 (14) 21 (6)
27 (7)
28 (8) 66.19 (10.12)
217 (59)
<0.001
0.002
0.95
152 (41)
1937.91 (612.06) 0.28 8.82 (0.83;24.47) 0.75
27.32 (4.43) 0.21 165.97 (9.11) 0.50
77 (21) 98 (27) 192 (52) 2 (1)
165 (45) 134 (36) 67 (18) 3 (1)
94 (25) 106 (29) 107 (29) 62 (17)
136 (37) 55 (15) 47 (13) 118 (32) 13 (4)
258 (70) 108 (29) 3 (1)
333 (90)
36 (10)
199(54) 150 (41) 20 (5)
0.004
0.39
0.54
0.50
<0.001
<0.001
0 - I-IV - Unknown -
SD: standard deviation; IQI: interquartile interval; BMI: Body Mass Index. 1P-value for heterogeneity calculated with the Student t-test for comparison of normally distributed con- tinuous variables, with the Wilcoxon rank-sum test for comparison of non-normally distributed continuous variables (alcohol intake), and with the χ2 test for categorical vari- ables. 2% of missing values in continuous variables: alcohol intake (2%), BMI (4%), height (3%). 3Waist-to-hip ratio risk categories according to WHO criteria. 4Physical activity, in the last ten years, measured in METs/week: inactive (0), low (0.1-8), moderate (8-15.9), and very active (≥16). In bold: P<0.05.
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