Page 141 - 2018_11-Haematologica-web

Chronic Lymphocytic Leukemia
Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
Ferrata Storti Foundation
Marta Solans,1,2,3* Adela Castelló,1,4,5* Yolanda Benavente,1,6
Rafael Marcos-Gragera,2,3 Pilar Amiano,1,7 Esther Gracia-Lavedan,1,8,9
Laura Costas,6 Claudia Robles,10 Eva Gonzalez-Barca,11
Esmeralda de la Banda,12 Esther Alonso,12 Marta Aymerich,13 Elias Campo,13 Trinidad Dierssen-Sotos,1,14 Guillermo Fernández-Tardón,1,15
Rocio Olmedo-Requena,1,16,17 Eva Gimeno,18 Gemma Castaño-Vinyals,1,8,9,19, Nuria Aragonés,1,20 Manolis Kogevinas,1,8,9,19 Silvia de Sanjose,1,6,21
Marina Pollán1,4** and Delphine Casabonne1,6**
Haematologica 2018 Volume 103(11):1881-1888
1Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 2Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Spain; 3Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology, Girona, Spain; 4Cancer Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain; 5Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain; 6Unit of Molecular Epidemiology and Genetic in Infections and Cancer (UNIC-Molecular), Cancer Epidemiology Research Programme (IDIBELL), Catalan Institute of Oncology, L' Hospitalet De Llobregat, Spain; 7Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain; 8ISGlobal, Barcelona, Spain; 9Universitat Pompeu Fabra (UPF), Barcelona, Spain; 10Unit of Information and Interventions in Infections and Cancer (UNIC-I&I), Cancer Epidemiology Research Programme, (IDIBELL), Catalan Institute of Oncology, L' Hospitalet De Llobregat, Spain; 11Hematology, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain; 12Hematology Laboratory, Department of Pathology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain; 13Hospital Clinic de Barcelona, University of Barcelona, CIBERONC, Barcelona Spain; 14University of Cantabria - Marqués de Valdecilla Research Institute (IDIVAL), Santander, Spain; 15University Institute of Oncology (IUOPA), University of Oviedo, Spain; 16Department of Preventive Medicine and Public Health, University of Granada, Spain; 17Instituto de Investigación Biosanitaria de Granada, Hospitales Universitarios de Granada, Spain; 18Hematology Department, Hospital del Mar, Barcelona, Spain; 19Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; 20Epidemiology Section, Public Health Division, Department of Health of Madrid, Spain and 21PATH, Reproductive Health, Seattle, WA, USA
*MS and AC contributed equally to this work. **MP and DC contributed equally to this work.
ABSTRACT
Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous stud- ies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to eval- uate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC- Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independent- ly of Rai stages. No differences in the association were observed accord- ing to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary pat- terns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a propor- tion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.
Correspondence:
dcasabonne@iconcologia.net
Received: March 6, 2018. Accepted: June 25, 2018. Pre-published: June 28, 2018.
doi:10.3324/haematol.2018.192526
Check the online version for the most updated information on this article, online supplements, and information on authorship & disclosures: www.haematologica.org/content/103/11/1881
©2018 Ferrata Storti Foundation
Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or inter- nal use. Sharing published material for non-commercial pur- poses is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for com- mercial purposes is not allowed without permission in writing from the publisher.
haematologica | 2018; 103(11)
1881
ARTICLE