Page 26 - 2018_10-Haematologica-web
P. 26

F. Grimolizzi and L. Arranz et al. References
1. Wise DR, Ward PS, Shay JES, et al. Hypoxia promotes isocitrate dehydrogenase-depen- dent carboxylation of -ketoglutarate to cit- rate to support cell growth and viability. Proc Natl Acad Sci USA. 2011;10(49):19611- 19616.
2. Kelly B, O'Neill LA. Metabolic reprogram- ming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771- 784.
3. Tannahill GM, Curtis AM, Adamik J, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-242.
4. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107(1):43-54.
5. Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel- Lindau ubiquitylation complex by O2-reg- ulated prolyl hydroxylation. Science. 2001;292(5516):468-472.
6. Selak MA, Armour SM, MacKenzie ED, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005;7(1):77-85.
7. Morin A, Letouze' E, Gimenez-Roqueplo AP, Favier J. Oncometabolites-driven tumorigen- esis: From genetics to targeted therapy. Int J Cancer. 2014;135(10):2237-2248.
8. Xie Z, Dai J, Dai L, et al. Lysine Succinylation and Lysine Malonylation in Histones. Mol Cell Proteomics. 2012;11(5): 100-107.
9. Park J, Chen Y, Tishkoff DX, et al. SIRT5- mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013;50(6):919-930.
10. Zhang ZH, Tan MJ, Xie ZY, Dai LZ, Chen Y, Zhao YM. Identification of lysine succiny- lation as a new post-translational modifica- tion. Nat Chem Biol. 2011;7(1):58-63.
11. Willmes DM, Birkenfeld AL. The Role of INDY in Metabolic Regulation. Comput Struct Biotechnol J. 2013;6:e201303020.
12. Rubic T, Lametschwandtner G, Jost S, et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008;9(11):1261-1269.
13. Kushnir MM, Komaromy-Hiller G, Shushan B, Urry FM, Roberts WL. Analysis of dicar- boxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. Clin Chem. 2001;47(11):1993- 2002.
14. Sadagopan N, Li W, Roberds SL, et al. Circulating succinate is elevated in rodent models of hypertension and metabolic dis- ease. Am J Hypertens. 2007;20(11):1209- 1215.
15. Hochachka PW, Dressendorfer RH. Succinate accumulation in man during exer- cise. Eur J Appl Physiol Occup Physiol. 1976;35(4):235-242.
16. van Diepen JA, Robben JH, Hooiveld GJ, et al. SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes. Diabetologia. 2017;60(7):1304-1313.
17. Serena C, Ceperuelo-Mallafré V, Keiran N, et al. Elevated circulating levels of succinate in human obesity are linked to specific gut
microbiota. ISME J. 2018;12(7):1642-1657. 18. Kohlhauer M, Dawkins S, Costa ASH, et al. Metabolomic Profiling in Acute ST- Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury. J Am
Heart Assoc. 2018;7(8).
19. Renella R, Carnevale J, Schneider KA,
Hornick JL, Rana HQ, Janeway KA. Exploring the association of succinate dehy- drogenase complex mutations with lym- phoid malignancies. Fam Cancer. 2014;13 (3):507-511.
20. Peruzzotti-Jametti L, Bernstock JD, Vicario N, et al. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell. 2018;22(3):355-368.
21. Cervera AM, Bayley JP, Devilee P, McCreath KJ. Inhibition of succinate dehydrogenase dysregulates histone modification in mam- malian cells. Mol Cancer. 2009;8:89.
22. Xiao M, Yang H, Xu W, et al. Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012;26(12):1326-1338.
23. DuJ,ZhouY,SuX,etal.Sirt5isaNAD- dependent protein lysine demalonylase and desuccinylase. Science. 2011;334(6057):806- 809.
24. Jones R, McDonald KE, Willson JA, et al. Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival inde- pendent of HIF-1alpha expression. Blood. 2016;127(21):2641-2644.
25. Mills EL, Kelly B, Logan A, et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167 (2):457-470.
26. Lampropoulou V, Sergushichev A, Bambouskova M, et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016;24(1):158-166.
27. Wang F, Wang K, Xu W, et al. SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1beta Production and to Prevent DSS-Induced Colitis in Mice. Cell Rep. 2017;19(11):2331- 2344.
28. Hogberg C, Gidlof O, Tan C, et al. Succinate independently stimulates full platelet activa- tion via cAMP and phosphoinositide 3- kinase-beta signaling. J Thromb Haemost. 2011;9(2):361-372.
29. Sundstrom L, Greasley PJ, Engberg S, Wallander M, Ryberg E. Succinate receptor GPR91, a Galpha(i) coupled receptor that increases intracellular calcium concentra- tions through PLCbeta. FEBS Lett. 2013;587(15):2399-2404.
30. He W, Miao FJ, Lin DC, et al. Citric acid cycle intermediates as ligands for orphan G- protein-coupled receptors. Nature. 2004;429 (6988):188-193.
31. Correa PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH. Succinate is a paracrine signal for liver damage. J Hepatol. 2007;47(2):262-269.
32. Robben JH, Fenton RA, Vargas SL, et al. Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells. Kidney Int. 2009;76(12):1258- 1267.
33. McCreath KJ, Espada S, Gálvez BG, et al.
Targeted disruption of the SUCNR1 meta- bolic receptor leads to dichotomous effects on obesity. Diabetes. 2015;64(4):1154- 1167.
34. Littlewood-Evans A, Sarret S, Apfel V, et al. GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. J Exp Med. 2016;213(9):1655-1662.
35. Rubi -Schneider T, Carballido-Perrig N, Regairaz C, et al. GPR91 deficiency exacer- bates allergic contact dermatitis while reduc- ing arthritic disease in mice. Allergy. 2017;72(3):444-452.
36. Geubelle P, Gilissen J, Dilly S, et al. Identification and pharmacological charac- terization of succinate receptor agonists. Br J Pharmacol. 2017;174(9):796-808.
37. Bhuniya D, Umrani D, Dave B, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011;21(12):3596-3602.
38. Hakak Y, Lehmann-Bruinsma K, Phillips S, et al. The role of the GPR91 ligand succinate in hematopoiesis. J Leukoc Biol. 2009;85 (5):837-843.
39. Macaulay IC, Tijssen MR, Thijssen- Timmer DC, et al. Comparative gene expression profiling of in vitro differentiat- ed megakaryocytes and erythroblasts iden- tifies novel activatory and inhibitory platelet membrane proteins. Blood. 2007;109(8):3260-3269.
40. Bejarano-Garcia JA, Millan-Ucles A, Rosado IV, et al. Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion. Cell Death Dis. 2016;7(12) :e2516.
41. Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014;505(7483):327-334.
42. Guo Y, Xie C, Li X, et al. Succinate and its G- protein-coupled receptor stimulates osteo- clastogenesis. Nat Commun. 2017;8:15621.
43. Miyamoto K, Yoshida S, Kawasumi M, et al. Osteoclasts are dispensable for hematopoi- etic stem cell maintenance and mobilization. J Exp Med. 2011;208(11):2175-2181.
44. Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 2004;103(9): 3258-3264.
45. Zhu X1, Gui J, Dohkan J, Cheng L, Barnes PF, Su DM. Lymphohematopoietic progeni- tors do not have a synchronized defect with age-related thymic involution. Aging Cell. 2007;6(5):663-672.
46. Takubo K, Goda N, Yamada W, et al. Regulation of the HIF-1 alpha Level Is Essential for Hematopoietic Stem Cells. Cell Stem Cell. 2010;7(3):391-402.
47. Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011;9(4): 298-310.
48. Crane GM, Jeffery E, Morrison SJ. Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017;17(9):573-590.
49. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med. 2008;14(10):1067- 1076.
50. Arranz L, Arriero MDM, Villatoro A. Interleukin-1beta as emerging therapeutic target in hematological malignancies and potentially in their complications. Blood Rev. 2017;31(5):306-317.
1592
haematologica | 2018; 103(10)


































































































   24   25   26   27   28