Page 41 - Haematologica August 2018

CARD10 regulates granulocytic differentiation
to H. Phillip Koeffler (NMRC/STaR/0021/2014), Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2013-T2-2-150), the NMRC Centre Grant awarded to National University Cancer Institute of Singapore (NMRC/CG/012/2013) and the National Research Foundation Singapore and the Singapore Ministry of Education
under its Research Centres of Excellence initiatives. This research is also supported by the RNA Biology Centre at the Cancer Science Institute of Singapore, NUS, as part of funding under the Singapore Ministry of Education’s Tier 3 grants, grant number MOE2014-T3-1-006. This paper is dedicated to the memory of Parker Hughes.
References
1. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631-644.
2. Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcrip- tional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
3. Tenen DG, Hromas R, Licht JD, Zhang DE. Transcription factors, normal myeloid development, and leukemia. Blood. 1997;90(2):489-519.
4. Iwasaki H, Somoza C, Shigematsu H, et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005; 106(5):1590-1600.
5. Hock H, Hamblen MJ, Rooke HM, et al. Intrinsic requirement for zinc finger tran- scription factor Gfi-1 in neutrophil differen- tiation. Immunity. 2003;18(1):109-120.
6. Holtschke T, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myeloge- nous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996;87(2):307-317.
7. Growney JD, Shigematsu H, Li Z, et al.
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood. 2005;106(2):494-504.
8. Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373(6513):432-434.
9. Yamanaka R, Barlow C, Lekstrom-Himes J, et al. Impaired granulopoiesis, myelodys-
plasia, and early lethality in CCAAT/enhancer binding protein epsilon- deficient mice. Proc Natl Acad Sci USA. 1997;94(24):13187-13192.
10. Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimu- lating factor signaling and neutrophil devel- opment in CCAAT enhancer binding pro- tein alpha-deficient mice. Proc Natl Acad Sci USA. 1997;94(2):569-574.
11. Akagi T, Thoennissen NH, George A, et al. In vivo deficiency of both C/EBPbeta and C/EBPepsilon results in highly defective myeloid differentiation and lack of cytokine response. PLoS One. 2010; 5(11):e15419.
12. Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP. Cloning of the novel human myeloid-cell-specific C/EBP- epsilon transcription factor. Mol Cell Biol. 1997;17(3):1375-1386.
13. Lekstrom-Himes J, Xanthopoulos KG. Biological role of the CCAAT/enhancer- binding protein family of transcription fac- tors. J Biol Chem. 1998;273(44):28545- 28548.
14. Morosetti R, Park DJ, Chumakov AM, et al. A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during gran- ulocytic, but not monocytic, differentia- tion. Blood. 1997;90(7):2591-2600.
15. Gombart AF, Shiohara M, Kwok SH, Agematsu K, Komiyama A, Koeffler HP. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Blood. 2001; 97(9):2561-2567.
16. Wada T, Akagi T, Muraoka M, et al. A novel in-frame deletion in the leucine zip- per domain of C/EBPepsilon leads to neu- trophil-specific granule deficiency. J Immunol. 2015;195(1):80-86.
17. Gombart AF, Krug U, O'Kelly J, An E, Vegesna V, Koeffler HP. Aberrant expres- sion of neutrophil and macrophage-related genes in a murine model for human neu- trophil-specific granule deficiency. J Leukoc Biol. 2005;78(5):1153-1165.
18. Grabiner BC, Blonska M, Lin PC, et al. CARMA3 deficiency abrogates G protein- coupled receptor-induced NF-{kappa}B acti- vation. Genes Dev. 2007;21(8):984-996.
19. Blonska M, Lin X. NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res. 2011;21(1):55- 70.
20. Medoff BD, Landry AL, Wittbold KA, et al.
CARMA3 mediates lysophosphatidic acid- stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol. 2009;40(3):286-294.
21. Suh HC, Benoukraf T, Shyamsunder P, et al. LPS independent activation of the pro- inflammatory receptor Trem1 by C/EBPepsilon in granulocytes. Sci Rep. 2017;7:46440.
22. Lara-Astiaso D, Weiner A, Lorenzo-Vivas E, et al. Immunogenetics. Chromatin state dynamics during blood formation. Science. 2014;345(6199):943-949.
23. Tanaka M, Gombart AF, Koeffler HP, Shiohara M. Expression of bactericidal/per- meability-increasing protein requires C/EBP epsilon. Int J Hematol. 2007;85(4):304-311.
24. Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP. Regulation of neutrophil and eosinophil secondary granule gene expression by tran- scription factors C/EBP epsilon and PU.1. Blood. 2003;101(8):3265-3273.
25. Chumakov AM, Kubota T, Walter S, Koeffler HP. Identification of murine and human XCP1 genes as C/EBP-epsilon- dependent members of FIZZ/Resistin gene family. Oncogene. 2004;23(19):3414-3425.
26. Khanna-Gupta A, Zibello T, Sun H, Gaines P, Berliner N. Chromatin immunoprecipita- tion (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid matura- tion-induced lactoferrin gene expression. Blood. 2003;101(9):3460-3468.
27. McDonald PP, Bald A, Cassatella MA. Activation of the NF-kappaB pathway by inflammatory stimuli in human neu- trophils. Blood. 1997;89(9):3421-3433.
28. Cassatella MA. The production of cytokines by polymorphonuclear neu- trophils. Immunol Today. 1995;16(1):21-26.
29. Kyme P, Thoennissen NH, Tseng CW, et al. C/EBPepsilon mediates nicotinamide- enhanced clearance of Staphylococcus aureus in mice. J Clin Invest. 2012; 122(9):3316-3329.
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