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SPOTLIGHT REVIEW ARTICLE - Coagulation factors and endothelial functionality C. Olgasi et al.
36. Sluka SHM, Akhmedov A, Vogel J, et al. Alternatively spliced tissue factor is not sufficient for embryonic development. PLoS One. 2014;9(5):e97793.
37. Carmeliet P, Mackman N, Moons L, et al. Role of tissue factor in embryonic blood vessel development. Nature. 1996;383(6595):73-75.
38. Zhu T, Mancini JA, Sapieha P, et al. Cortactin activation by FVIIa/ tissue factor and PAR2 promotes endothelial cell migration. Am J Physiol Regul Integr Comp Physiol. 2011;300(3):R577-585.
39. Rezaie AR, Giri H. Anticoagulant and signaling functions of antithrombin. J Thromb Haemost. 2020;18(12):3142-3153.
40. Panicker SR, Biswas I, Giri H, Cai X, Rezaie AR. PKC (protein kinase C)-δ modulates AT (antithrombin) signaling in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2020;40(7):1748-1762.
41. Zhang W, Chuang YJ, Jin T, et al. Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells. Cancer Res. 2006;66(10):5047-5055.
42. O’Reilly MS, Pirie-Shepherd S, Lane WS, Folkman J. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science. 1999;285(5435):1926-1928.
43. Hsu Y-Y, Shi G-Y, Wang K-C, et al. Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin. Oncotarget. 2016;7(42):68122-68139.
44. Shi CS, Shi GY, Chang YS, et al. Evidence of human thrombomodulin domain as a novel angiogenic factor. Circulation. 2005;111(13):1627-1636.
45. Kuo CH, Chen PK, Chang BI, et al. The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through
interaction with Lewis Y antigen. Blood. 2012;119(5):1302-1313. 46. Giri H, Panicker SR, Cai X, Biswas I, Weiler H, Rezaie AR.
Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells. Proc Natl Acad Sci U S A. 2021;118(11):e2022248118.
47. Minhas N, Xue M, Jackson CJ. Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function. Cell Mol Life Sci. 2017;74(10):1895-1906.
48. Soh UJK, Trejo JA. Activated protein C promotes protease- activated receptor-1 cytoprotective signaling through b-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011;108(50):E1372-E1380.
49. Molinar-Inglis O, Birch CA, Nicholas D, et al. aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, b-arrestin-2- mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021;118(49):e2106623118.
50. Cui J, O’Shea KS, Purkayastha A, Saunders TL, Ginsburg D. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature. 1996;384(6604):66-68.
51. Dardik R, Loscalzo J, Inbal A. Factor XIII (FXIII) and angiogenesis. J Thromb Haemost. 2006;4(1):19-25.
52. Mamiya A, Kitano H, Kokubun S, Hidai C. Activation peptide of coagulation factor IX regulates endothelial permeability. Transl Res. 2016;177:70-84.
53. Reinhardt C, Manukyan D, Ruf W. The role of coagulation factor signaling in angiogenesis and vascular remodeling. Endothel Sign Develop Dis. 2015;233-256.
54. Walker GE, Merlin S, Zanolini D, et al. Factor VIII as a potential player in cancer pathophysiology. J Thromb Haemost. 2022;20(3):648-660.
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