Page 331 - Haematologica Vol. 109 - July 2024

LETTER TO THE EDITOR
marrow microenvironment may provide signaling to regulate this internal factor during proplatelet production.
Authors
Joseph E. Italiano Jr1,2 and Kellie R. Machlus1,2
1Vascular Biology Program, Department of Surgery, Boston Children’s Hospital and 2Harvard Medical School, Boston, MA, USA
Correspondence:
J. ITALIANO - joseph.italiano@childrens.harvard.edu
https://doi.org/10.3324/haematol.2023.284755
Received: November 25, 2023. Accepted: February 19, 2024. Early view: February 29, 2024.
©2024 Ferrata Storti Foundation Published under a CC BY-NC license
Disclosures
JEI has a financial interest in and is a founder of StellularBio, a biotechnology company focused on making donor-independent
References
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3. Radley JM, Scurfield G. The mechanism of platelet release. Blood. 1980;56(6):996-999.
4. Italiano JE Jr, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999;147(6):1299-1312.
5. Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE Jr. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005;106(13):4066-4075.
6. Thon JN, Macleod H, Begonja AJ, et al. Microtubule and cortical
platelet-like cells at scale, and has a financial interest in and is a founder of SpryBio, a biotechnology company focused on using shelf-stable platelets to treat osteoarthritis. His interests are managed by the Boston Children’s Hospital. KRM has no conflicts of interest to disclose.
Contributions
JEI conceptualized and designed the research, conducted the experiments, analyzed and interpreted the data, and wrote the manuscript. KRM designed and interpreted the research, and edited and reviewed the manuscript.
Acknowledgments
We thank Dani Freire, Emma Nikols, Clementine Payne and Karen Guo for critical reading of the manuscript.
Funding
JEI is supported by the National Institute of Health, National Heart, Lung, and Blood Institute (R01HL68130 and R35HL161175). KRM is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R03DK124746) and the National Heart, Lung, and Blood Institute (R01HL151494).
Data-sharing statement
Please contact the corresponding author for access to the original data related to this manuscript.
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