Page 253 - Haematologica Vol. 109 - July 2024
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ARTICLE - Application of CAAR T-cell therapy in ITP J. Zhou et al. AB
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Figure 6. GPIbα chimeric autoantibody receptor T cells recognized and eliminated autoreactive B cells from immune thrombo- cytopenia patients. (A) Plasma from 3 immune thrombocytopenia (ITP) patients with anti-GPIb antibodies and healthy controls was diluted at 1:10 and 1:20 and incubated with HEK293T cells expressing ligand-binding domain LBD-mutg233k-chimeric auto- antibody receptor (CAAR)-tagged with green fluorescent protein (GFP). The cells were then stained with anti-human immuno-
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