Page 17 - Haematologica Vol. 109 - July 2024

EDITORIAL
M. Alberich-Jorda and L. Macurek
References
1. Lu Z, Yu H, Li Y, et al. Phosphatase, Mg2+/Mn2+ dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/ b-catenin signaling. Haematologica. 2024;109(7):2144-2156.
2. Lu Z, Xiao P, Zhou Y, et al. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. J Cell Mol Med. 2020;24(22):13463-13471.
3. Liu X, Zhang F, Zhang Y, et al. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Rep. 2018;23(5):1461-1475.
4. Chen Z, Yi W, Morita Y, et al. Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways. Nat Commun. 2015;6:6808.
5. Burocziova M, Danek P, Oravetzova A, Chalupova Z, Alberich- Jorda M, Macurek L. Ppm1d truncating mutations promote the development of genotoxic stress-induced AML. Leukemia. 2023;37(11):2209-2220.
6. Miller PG, Sperling AS, Mayerhofer C, et al. PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood.
2023;142(24):2079-2091.
7. Gilmartin AG, Faitg TH, Richter M, et al. Allosteric Wip1
phosphatase inhibition through flap-subdomain interaction. Nat
Chem Biol. 2014;10(3):181-187.
8. Carpenter KA, Thurlow KE, Craig SEL, Grainger S. Wnt regulation
of hematopoietic stem cell development and disease. Curr Top
Dev Biol. 2023;153:255-279.
9. Xu Y, Banerjee D, Huelsken J, Birchmeier W, Sen JM. Deletion of
beta-catenin impairs T cell development. Nat Immunol.
2003;4(12):1177-1182.
10. Ranheim EA, Kwan HCK, Reya T, Wang Y-K, Weissman IL,
Francke U. Frizzled 9 knock-out mice have abnormal B-cell
development. Blood. 2005;105(6):2487-2494.
11. Danek P, Kardosova M, Janeckova L, et al. b-Catenin-TCF/LEF
signaling promotes steady-state and emergency granulopoiesis
via G-CSF receptor upregulation. Blood. 2020;136(22):2574-2587. 12. Hérault A, Binnewies M, Leong S, et al. Myeloid progenitor
cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544(7648):53-58.
Haematologica | 109 July 2024
2031