Page 142 - Haematologica Vol. 109 - July 2024
P. 142

ARTICLE - Ppm1b regulates HSC homeostasis
Z. Lu et al.
signatures of seven individual human embryonic stem cell lines.
Stem Cells. 2005;23(9):1343-1356.
22. Sasaki M, Ohnishi M, Tashiro F, et al. Disruption of the mouse
protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-
implantation lethality. Mech Dev. 2007;124(6):489-499.
23. Lu ZY, Xiao P, Zhou Y, et al. Identification of HN252 as a potent
inhibitor of protein phosphatase PPM1B. J Cell Mol Med.
2020;24(22):13463-13471.
24. Yien YY, Bieker JJ. Functional Interactions between erythroid
Kruppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/
PP2C beta. J Biol Chem. 2012;287(19):15193-15204.
25. Lu ZY, Huang LX, Li YX, et al. Fine-tuning of cholesterol homeostasis controls erythroid differentiation. Adv Sci.
2022;9(2):2102669.
26. Lu ZY, Xu GS, Li YX, Lu CH, Shen YM, Zhao BB. Discovery of
N-arylcinnamamides as novel erythroblast enucleation inducers.
Bioorg Chem. 2022;128:106105.
27. Mei Y, Han X, Liu YJ, Yang J, Sumagin R, Ji P. Diaphanous-related
formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Nat Commun. 2020;11(1):3172.
28. Blanchard EL, Loomis KH, Bhosle SM, et al. Proximity ligation assays for in situ detection of innate immune activation: focus on in vitro-transcribed mRNA. Mol Ther Nucleic Acids. 2019;14:52-66.
29. Tario JD, Humphrey K, Bantly AD, Muirhead KA, Moore JS, Wallace PK. Optimized staining and proliferation modeling methods for cell division monitoring using cell tracking dyes. J Vis Exp. 2012;70:e4287.
30. Filby A, Begum J, Jalal M, Day W. Appraising the suitability of succinimidyl and lipophilic fluorescent dyes to track proliferation in non-quiescent cells by dye dilution. Methods. 2015;82:29-37.
31. Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S. Long-term ex vivo expansion of mouse hematopoietic stem cells. Nat Protoc. 2020;15(2):628-648.
32. Wilkinson AC, Nakauchi H. Stabilizing hematopoietic stem cells in vitro. Curr Opin Genet Dev. 2020;64:1-5.
33. Klein C, Zwick A, Kissel S, et al. Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. J Exp Med. 2016;213(2):273-290.
34. Yang L, Bryder D, Adolfsson J, et al. Identification of Lin(-)Sca1(+) kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood. 2005;105(7):2717-2723.
35. Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121(7):1109-1121.
36. Takebe N, Zhao SC, Ural AU, et al. Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34(+)-enriched peripheral blood progenitor cells. Cancer Gene Ther. 2001;8(12):966-973.
37. Nutt SL, Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity. 2007;26(6):715-725.
38. Lehnertz B, Chagraoui J, MacRae T, et al. HLF expression defines the human hematopoietic stem cell state. Blood. 2021;138(25):2642-2654.
39. Freire PR, Conneely OM. NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling. Blood. 2018;131(10):1081-1093.
40. Okada S, Fukuda T, Inada K, Tokuhisa T. Prolonged expression of
c-fos suppresses cell cycle entry of dormant hematopoietic stem
cells. Blood. 1999;93(3):816-825.
41. Jeong M, Piao ZH, Kim MS, et al. Thioredoxin-interacting protein
regulates hematopoietic stem cell quiescence and mobilization
under stress conditions. J Immunol. 2009;183(4):2495-2505. 42. Gotze KS, Ramirez M, Tabor K, Small D, Matthews W, Civin CI.
Flt3(high) and Flt3(low) CD34(+) progenitor cells isolated from human bone marrow are functionally distinct. Blood. 1998;91(6):1947-1958.
43. Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. A small- molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005;44(13):1987-1990.
44. Pietras EM, Warr MR, Passegue E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011;195(5):709-720.
45. Nakamura-Ishizu A, Takizawa H, Suda T. The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development. 2014;141(24):4656-4666.
46. Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet. 2008;9(2):115-128.
47. Richter J, Traver D, Willert K. The role of Wnt signaling in hematopoietic stem cell development. Crit Rev Biochem Mol Biol. 2017;52(4):414-424.
48. Carpenter KA, Thurlow KE, Craig SEL, Grainger S. Wnt regulation of hematopoietic stem cell development and disease. Curr Top Dev Biol. 2023;153:255-279.
49. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423(6938):409-414.
50. Baba Y, Yokota T, Spits H, Garrett KP, Hayashi SI, Kincade PW. Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol. 2006;177(4):2294-2303.
51. Kirstetter P, Anderson K, Porse BT, Jacobsen SEW, Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol. 2006;7(10):1048-1056.
52. Scheller M, Huelsken J, Rosenbauer F, et al. Hematopoietic stem cell and multilineage defects generated by constitutive beta- catenin activation. Nat Immunol. 2006;7(10):1037-1047.
53. Reya T, O’Riordan M, Okamura R, et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000;13(1):15-24.
54. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91(5):661-672.
55. Porritt HE, Rumfelt LL, Tabrizifard S, et al. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity. 2004;20(6):735-745.
56. Allman D, Sambandam A, Kim S, et al. Thymopoiesis independent of common lymphoid progenitors. Nat Immunol. 2003;4(2):168-174.
57. Schwarz BA, Bhandoola A. Circulating hematopoietic progenitors with T lineage potential. Nat Immunol. 2004;5(9):953-960.
58. Inlay MA, Bhattacharya D, Sahoo D, et al. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev. 2009;23(20):2376-2381.
59. Ghaedi M, Steer CA, Martinez-Gonzalez I, Halim TYF, Abraham N, Takei F. Common-lymphoid-progenitor-independent pathways of innate and T lymphocyte development. Cell Rep. 2016;15(3):471-480.
Haematologica | 109 July 2024
2156









































   140   141   142   143   144