Page 108 - Haematologica Vol. 109 - July 2024

ARTICLE - Acute Myeloid Leukemia
Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study
Annalisa Ruggeri,1* Nicole Santoro,2* Jacques-Emmanuel Galimard,3 Krzysztof Kalwak,4 Mattia Algeri,5,6 Ludmila Zubarovskaya,7 Krzysztof Czyzewski,8 Elena Skorobogatova,9 Petr Sedlacek,10 Caroline Besley,11 Adriana Balduzzi,12,13 Yves Bertrand,14 Julia Peristeri,15 Franca Fagioli,16 Mariane Ifversen,17 Jolanta Gozdzik,18 Christina Peters,19 Birgitta Versluijs,20 Alessandra Biffi,21 Arcangelo Prete,22 Maura Faraci,23 Ibrahim Ghemlas,24 Ivana Bodova,25 Olga Aleinikova,26 Arnaud Dalissier,27 Vanderson Rocha28 and Selim Corbacioglu29
1IRCCS San Raffaele Scientific Institute, Milano, Italy; 2Hematology Unit, Department of Oncology and Hematology, Santo Spirito Hospital, Pescara, Italy; 3EBMT Statistical Unit, Paris, France; 4Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland; 5Department of Pediatric Hematology Oncology, IRCCS Bambino Gesu Children’ s Hospital, Rome, Italy; 6Department of Health Sciences, Magna Graecia University, Catanzaro, Italy; 7RM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russia; 8Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland; 9The Russian Children’ s Research Hospital, Department of Bone Marrow Transplantation, Moscow, Russia; 10University Hospital Motol, Department of Pediatric Hematology and Oncology, Prague, Czech Republic; 11Bristol Royal Hospital for Children, Department of Pediatric Oncology/BMT, Bristol, UK; 12Hematopoietic Stem Cell Transplantation Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; 13Department of Medicine and Surgery, Milano-Bicocca University, Monza, Italy; 14Institut d`Hematologie et d`Oncologie Pediatrique, Lyon, France; 15St Sophia Children’s Hospital Oncology Center, Athens, Greece; 16Onco-Ematologia Pediatrica Centro Trapianti Cellule Staminali, Torino, Italy; 17Copenhagen University Hospital, Rigshospitalet, Department of Children and Adolescents Medicine, Copenhagen, Denmark; 18Department of Clinical Immunology and Transplantation, Jagiellonian University Medical College, Children’s Hospital, Krakow, Poland; 19St. Anna Children’s Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria; 20Princess Maxima Center, Utrecht, the Netherlands; 21Clinica di Oncoematologia Pediatrica, Dipartimento di Pediatria, Padova, Italy; 22IRCCS-Azienda Ospedaliero Universitaria, Bologna, Italy; 23HSCT Unit, Department Hemato-Oncology, IRCSS Istituto G. Gaslini, Genova, Italy; 24Pediatric Hematology/Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; 25Pediatric University Teaching Hospital BMT Unit, II Children`s Clinic Bratislava, Slovakia; 26Belorussian Center for Pediatric Oncology and Hematology, Minsk, Russia; 27EBMT Paris Study Unit, Paris, France; 28BMT Unit, Sao Paolo University, Sao Paolo, Brasil and 29University of Regensburg, Regensburg, Germany
*AR and NS contributed equally as first authors.
Abstract
In children with acute myeloid leukemia (AML) who lack a human leukocyte antigen (HLA) identical sibling, the donor can be replaced with an HLA-matched unrelated donor (MUD) or a haploidentical donor (haplo). We compared outcomes of patients <18 years with AML in first and second complete remission (CR1 & CR2) undergoing a hematopoietic stem cell transplantation (HCT) either with a MUD with anti-thymocyte globulin (ATG) (N=420) or a haplo HCT with post-transplant cyclophosphamide (PT-CY) (N=96) after a myeloablative conditioning regimen (MAC) between 2011 and 2021, reported to the
Haematologica | 109 July 2024
Correspondence: A. Ruggeri ruggeri.annalisa@hsr.it
Received: Accepted: Early view:
October 26, 2023. December 28, 2023. January 4, 2024.
https://doi.org/10.3324/haematol.2023.284445
©2024 Ferrata Storti Foundation Published under a CC BY-NC license
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