Page 103 - Haematologica Vol. 109 - July 2024

ARTICLE - CD47 inhibition is augmented with TLR3 agonism H.E. Ramsey et al. AB
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Figure 5. The activity of polyinosinic:polycytidylic acid on murine macrophages. (A) Polyinosinic:polycytidylic acid (poly(I:C)) leads to overall shifts in macrophage populations in the bone marrow (BM), spleen (SPL) and peripheral blood of treated mice. Shifts in M1/M2 ratio develop across compartments (B) while macrophage numbers increase (C) upon poly(I:C) administration. *P<0.05, **P<0.01 and ***P<0.001.
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Figure 6. The addition of polyinosinic:polycytidylic acid to a venetoclax/azacitidin regimen augments CD47 inhibition in a patient-de- rivedxenograftmodel.(A)Peripheralchimerismand(B)endpointanalysisofavenetoclax/azacitidinplusALX (VEN/AZA+ALX)regimen with the addition of polyinosinic:polycytidylic acid (poly(I:C)). (C) Immunohistochemistry for hCD45 reveals visible decreases in human cells with the bone marrow (BM) and spleen (SPL) of patient-derived xenograft (PDX) mice treated with VEN/AZA + ALX + poly(I:C). **P<0.01 and ***P<0.001.
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